// Research Publications

Click below for recent publications, or here for a comprensive list.

High-fructose diet during periadolescent development increases depressive-like behavior and remodels the hypothalamic transcriptome in male rats.

By: Harrell CS, Burgado J, Kelly SD, Johnson ZP, Neigh GN.

Psychoneuroendocrinology. 2015; 62:252-64


Prenatal stress, regardless of concurrent escitalopram treatment, alters behavior and amygdala gene expression of adolescent female rats. By: Ehrlich DE, Neigh GN, Bourke CH, Nemeth CL, Hazra R, Ryan SJ, Rowson S, Jairam N, Sholar C, Rainnie DG, Stowe ZN, Owens MJ. Neuropharmacology. 2015.


Pharmacological stimulation of hypoxia inducible factor-1α facilitates the corticosterone response to a mild acute stressor

By: Harrell, Constance S.; Rowson, Sydney A.; Neigh, Gretchen N. 

NEUROSCIENCE LETTERS; 2015 July 23. doi:10.1016/j.neulet.2015.05.051


Microemboli alter the acute stress response and cause prolonged expression of MCP-1 in the hippocampus.
By: Nemeth, Christina L.; Neigh, Gretchen N.

PSYCHONEUROENDOCRINOL; 2015 Feb 4.  doi:  10.1016/j.psyneuen.2015.01.023


Microglial activation occurs in the absence of anxiety-like behavior following microembolic stroke in female, but not male, rats.
By:  Nemeth, Christina L.; Reddy, Renuka; Bekhbat, Mandakh; et al.
J NEUROINFLAMM; 2014 Nov 6. 11(1):174. 


Meloxicam blocks neuroinflammation, but not depressive-like behaviors, in HIV-1 transgenic female rats

By:  Nemeth, Christina L.; Glasper, Erica R.; Harrell, Constance S.; et al.
PLOS ONE; 2014 Oct 1. 9(10):e108399. doi: 10.1371/journal.pone.0108399

Neural effects of inflammation, cardiovascular disease, and HIV: parallel, perpendicular, or progressive?

By:  Nemeth, Christina L.; Bekhbat, Mandkah.; Neigh, Gretchen N.

NEUROSCIENCE;  2014 Sep 16. pii: S0306-4522(14)00758-1. doi: 10.1016/j.neuroscience.2014.09.016.


Two weeks of predatory stress induces anxiety-like behavior with co-morbid depressive-like behavior in adult male mice

By:  Burgado Jillybeth; Harrell, Constance S.; Eacret, Darrell; et al.

BEHAVIORAL BRAIN RESEARCH. 2014 Sep 6. pii: S0166-4328(14)00579-8. 


SSRI or CRF antagonism partially ameliorates depressive-like behavior after adolescent social defeat 

By:  Bourke Chase H.; Glasper Erica R.; Neigh Gretchen N.

BEHAVIORAL BRAIN RESEARCH. 2014 Aug 15;270:295-9. 


Development of the HPA axis: Where and when do sex differences manifest?

By: Panagiotakopoulos, Leonidas; Neigh, Gretchen N.

FRONTIERS IN NEUROENDOCRINOLOGY  Volume: 35  Issue: 3   Special Issue: SI   Pages: 285-302   Published:AUG 2014


Heartsick: psychiatric and inflammatory implications of cerebromicrovascular disease

By: Nemeth, Christina L.; Haroon, Ebrahim; Neigh, Gretchen N.

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY  Volume: 29   Issue: 6   Pages: 577-585  Published: JUN 2014


Microembolism induces anhedonia but no detectable changes in white matter integrity in aged rats

By: Nemeth, Christina L.; Gutman, David A.; Majeed, Waqas; et al.

PLOS ONE  Volume: 9   Issue: 5     Article Number:e96624   Published: MAY 8 2014


Ovarian steroids influence cerebral glucose transporter expression in a region- and isoform-specific Pattern

By: Harrell, Constance S.; Burgado, Jilly B.; Kelly, Sean D.; et al.

JOURNAL OF NEUROENDOCRINOLOGY  Volume: 26  Issue: 4   Pages: 217-225   Published: APR 2014


Chronic stress modulates regional cerebral glucose transporter expression in an age-specific and sexually-dimorphic manner

By: Kelly, Sean D.; Harrell, Constance S.; Neigh, Gretchen N.

PHYSIOLOGY & BEHAVIOR  Volume: 126   Pages: 39-49  Published: MAR 14 2014


Estradiol activates epithelial sodium channels in rat alveolar cells through the G protein-coupled estrogen receptor

By: Greenlee, Megan M.; Mitzelfelt, Jeremiah D.; Yu, Ling; et al.



Estradiol stimulates an anti-translocation expression pattern of glucocorticoid co-regulators in a hippocampal cell model

By: Malviya, Sanjana A.; Kelly, Sean D.; Greenlee, Megan M.; et al.

PHYSIOLOGY & BEHAVIOR  Volume: 122   Special Issue:SI   Pages: 187-192   Published: OCT 2 2013


Translational reciprocity: Bridging the gap between preclinical studies and clinical treatment of stress effects on the adolescent brain

By: Neigh, Gretchen N.; Ritschel, L. A.; Kilpela, L. S.; et al.

NEUROSCIENCE  Volume: 249   Pages: 139-153  Published: SEP 26 2013


Prenatal exposure to escitalopram and/or stress in rats produces limited effects on endocrine, behavioral, or gene expression measures in adult male rats

By: Bourke, Chase H.; Stowe, Zachary N.; Neigh, Gretchen N.; et al.

NEUROTOXICOLOGY AND TERATOLOGY  Volume: 39  Pages: 100-109   Published: SEP-OCT 2013


Sex and lineage interact to predict behavioral effects of chronic adolescent stress in rats

By: Harrell, Constance S.; Hardy, Emily; Boss-Williams, Katherine; et al.

BEHAVIOURAL BRAIN RESEARCH  Volume: 248   Pages:57-61   Published: JUL 1 2013


Sex differences in the effects of adolescent stress on adult brain inflammatory markers in rats

By: Pyter, Leah M.; Kelly, Sean D.; Harrell, Constance S.; et al.

BRAIN BEHAVIOR AND IMMUNITY  Volume: 30   Pages:88-94   Published: MAY 2013


Not all depression is created equal: sex interacts with disease to precipitate depression

By: Nemeth, Christina L.; Harrell, Constance S.; Beck, Kevin D.; et al.

BIOLOGY OF SEX DIFFERENCES  Volume: 4     Article Number: 8   Published: APR 17 2013


Glucocorticoid sensitizers Bag1 and Ppid are regulated by adolescent stress in a sex-dependent manner

By: Bourke, Chase H.; Raees, Madiha Q.; Malviya, Sanjana; et al.

PSYCHONEUROENDOCRINOLOGY  Volume: 38   Issue: 1  Pages: 84-93   Published: JAN 2013


Microembolism infarcts lead to delayed changes in affective-like behaviors followed by spatial memory impairment

By: Nemeth, Christina L.; Shurte, Mallory S.; McTigue, Dana M.; et al.

BEHAVIOURAL BRAIN RESEARCH  Volume: 234   Issue: 2  Pages: 259-266   Published: OCT 1 2012


Stress-induced sex differences: Adaptations mediated by the glucocorticoid receptor

By: Bourke, Chase H.; Harrell, Constance S.; Neigh, Gretchen N.

HORMONES AND BEHAVIOR  Volume: 62   Issue: 3  Pages: 210-218   Published: AUG 2012


Exposure to repeated maternal aggression induces depressive-like behavior and increases startle in adult female rats

By: Bourke, Chase H.; Neigh, Gretchen N.

BEHAVIOURAL BRAIN RESEARCH  Volume: 227   Issue: 1  Pages: 270-275   Published: FEB 1 2012


Psychological stress in adolescent and adult mice increases neuroinflammation and attenuates the response to LPS challenge

By: Barnum, Christopher J.; Pace, Thaddeus W. W.; Hu, Fang; et al.

JOURNAL OF NEUROINFLAMMATION  Volume: 9    Article Number: 9   Published: JAN 16 2012

Behavioral effects of chronic adolescent stress are sustained and sexually dimorphic

By: Bourke, Chase H.; Neigh, Gretchen N.

HORMONES AND BEHAVIOR  Volume: 60   Issue: 1  Pages: 112-120   Published: JUN 2011

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